SRSF6

Across TCGA patient cohorts, SRSF6 mutation is significantly associated with the RNA expression of many other genes, with 3,368 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF6-associated genes across cancer lineages are RNA5SP509, RN7SKP181, and TUBGCP5. Each is linked with SRSF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRSF6-to-partner and partner-to-SRSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP509 grouped by SRSF6-low versus SRSF6-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF6→partner) and Y-score (partner→SRSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP509 →	+0.241	+7.051	<.001	<.001	3	3
BLCA	RN7SKP181 →	+0.122	+4.685	<.001	.007	3	3
UCEC	TUBGCP5 →	+0.423	+1.787	<.001	<.001	3	2
UCEC	EIF3JP1 →	+0.158	+1.783	<.001	.001	3	2
UCEC	PSMD10 →	+0.401	+1.562	.001	.002	3	2
UCEC	HTATSF1 →	+0.391	+2.700	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,368 associations by consensus.

RNA5SP509 by SRSF6 expression — BLCA

Explore this box plot interactively →