SRSF6

Across TCGA patient cohorts, SRSF6 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF6-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with SRSF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF6-to-partner and partner-to-SRSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SRSF6-low versus SRSF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF6→partner) and Y-score (partner→SRSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.242	-3.700	.004	.001	3	1
UCEC	eIF4E →	+0.162	+1.750	.024	.049	3	1
UCEC	A-Raf_pS299 →	-0.086	-1.700	.034	.042	3	1
UCEC	FoxM1 →	+0.200	+2.137	.023	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.094	-1.896	.027	.015	3	1
UCEC	INPP4B →	-0.289	-2.321	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR_pY1068 by SRSF6 expression — UCEC

Explore this box plot interactively →