SRSF6

Across TCGA cell cohorts, SRSF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,467 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRSF6-associated GO terms across cancer lineages are Promoter clearance during DNA-templated transcription, RNA polymerase II promoter clearance, and Regulation of DNA recombination. Each is linked with SRSF6 in more than 17 cancer types. Because this analysis shows association rather than direction, both SRSF6-to-partner and partner-to-SRSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Promoter clearance during DNA-templated transcription grouped by SRSF6-low versus SRSF6-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF6→partner) and Y-score (partner→SRSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Promoter clearance during DNA-templated transcription →	+0.147	+0.710	.001	<.001	3	18
LIVER	RNA polymerase II promoter clearance →	+0.147	+0.710	.001	<.001	3	18
BONE	Regulation of DNA recombination →	+0.094	+0.671	.004	.002	3	16
SOFT_TISSUE	Regulation of mRNA catabolic process →	+0.076	+1.170	<.001	<.001	3	16
BONE	Regulation of DNA repair →	+0.067	+0.602	<.001	<.001	3	16
BONE	Late viral transcription →	+0.163	+0.619	.001	.003	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,467 associations by consensus.

Promoter clearance during DNA-templated transcription by SRSF6 expression — LIVER

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