SRSF6

Across TCGA cell cohorts, SRSF6 mutation is significantly associated with the RNA expression of many other genes, with 156 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRSF6-associated genes across cancer lineages are MAGEB4, RBMY1F, and PLA2G3. Each is linked with SRSF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF6-to-partner and partner-to-SRSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by SRSF6-low versus SRSF6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF6→partner) and Y-score (partner→SRSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MAGEB4 →	+0.008	+4.437	<.001	.004	3	1
SKIN	RBMY1F →	+0.052	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PLA2G3 →	+1.096	+3.347	<.001	.005	3	1
LARGE_INTESTINE	GCAT →	+1.427	+3.169	<.001	.009	3	1
LARGE_INTESTINE	PIM2 →	+0.506	+3.064	.005	.009	3	1
LARGE_INTESTINE	HOXA2 →	-0.725	-3.278	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 156 associations by consensus.

MAGEB4 by SRSF6 expression — SKIN

Explore this box plot interactively →