SRSF5

Across TCGA pan-cancer cohorts, SRSF5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRSF5 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRSF5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SRSF5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, OV, and LSCC are the cancer types where SRSF5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.911	0.686	.008	16	view →
OV	DFS	Median	All	0.867	1.000	.035	4	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.694	.039	4	view →
CCRCC	OS	Median	II,III,IV	1.000	0.435	.015	2	view →
LUAD	DFS	Tertile	All	0.852	0.488	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRSF5–HNSC (DFS)

Open the HNSC breakdown →