SRSF5

Across TCGA patient cohorts, SRSF5 mutation is significantly associated with the RNA expression of many other genes, with 2,843 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF5-associated genes across cancer lineages are ATF4P2, RN7SL134P, and PABPC1P12. Each is linked with SRSF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF5-to-partner and partner-to-SRSF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF4P2 grouped by SRSF5-low versus SRSF5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF5→partner) and Y-score (partner→SRSF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATF4P2 →	+0.054	+4.241	<.001	.008	3	2
CESC	RN7SL134P →	+0.101	+3.874	.003	.006	3	2
BLCA	PABPC1P12 →	+0.070	+4.973	<.001	.009	3	2
COAD	MIR1302-5 →	+0.400	+5.003	.001	.004	3	2
CESC	RNA5SP198 →	+0.363	+5.729	<.001	<.001	3	2
SKCM	RPL34P19 →	+0.304	+4.381	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,843 associations by consensus.

ATF4P2 by SRSF5 expression — SKCM

Explore this box plot interactively →