SRSF5

Across TCGA cell cohorts, SRSF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,854 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRSF5-associated GO terms across cancer lineages are mRNA splice site recognition, Regulation of alternative mRNA splicing, via spliceosome, and mRNA 5'-splice site recognition. Each is linked with SRSF5 in more than 16 cancer types. Because this analysis shows association rather than direction, both SRSF5-to-partner and partner-to-SRSF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splice site recognition grouped by SRSF5-low versus SRSF5-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF5→partner) and Y-score (partner→SRSF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	mRNA splice site recognition →	+0.139	+0.643	<.001	<.001	3	17
LARGE_INTESTINE	Regulation of alternative mRNA splicing, via spliceosome →	+0.096	+0.685	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	mRNA 5'-splice site recognition →	+0.167	+1.326	<.001	<.001	3	15
OESOPHAGUS	Regulation of RNA splicing →	+0.080	+0.687	.001	.004	3	15
LUNG_SCLC	RNA destabilization →	+0.057	+0.688	.004	.005	3	15
LARGE_INTESTINE	Regulation of mRNA splicing, via spliceosome →	+0.081	+0.734	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,854 associations by consensus.

mRNA splice site recognition by SRSF5 expression — OESOPHAGUS

Explore this box plot interactively →