SRSF5

Across TCGA cell cohorts, SRSF5 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRSF5-associated genes across cancer lineages are JAKMIP1 and UBE2QL1. Each is linked with SRSF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF5-to-partner and partner-to-SRSF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JAKMIP1 grouped by SRSF5-low versus SRSF5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF5→partner) and Y-score (partner→SRSF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JAKMIP1 →	+0.262	+3.339	<.001	.007	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.254	+4.029	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

JAKMIP1 by SRSF5 expression — LARGE_INTESTINE

Explore this box plot interactively →