SRSF5

Across TCGA cell cohorts, SRSF5 mutation is significantly associated with the mutation status of many other genes, with 2,929 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRSF5-associated genes across cancer lineages are GTF3C3, RBM42, and CDC73. Each is linked with SRSF5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRSF5-to-partner and partner-to-SRSF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTF3C3 grouped by SRSF5-low versus SRSF5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF5→partner) and Y-score (partner→SRSF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GTF3C3 →	+2.407	+2.886	.008	.008	1	3
LARGE_INTESTINE	RBM42 →	+2.951	+3.793	<.001	<.001	1	3
LARGE_INTESTINE	CDC73 →	+2.407	+2.886	.008	.008	1	3
LARGE_INTESTINE	NAA30 →	+4.799	+3.672	.002	.002	1	3
LARGE_INTESTINE	CLBA1 →	+3.215	+3.954	<.001	<.001	1	3
LARGE_INTESTINE	GLRA1 →	+3.799	+3.329	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,929 associations by consensus.

GTF3C3 by SRSF5 expression — LARGE_INTESTINE

Explore this box plot interactively →