SRSF4

Across TCGA pan-cancer cohorts, SRSF4 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SRSF4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SRSF4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SRSF4 is over-expressed in tumor.

COAD, LUAD, and HNSC are the cancer types where SRSF4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRSF4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.448	<.001	11	view →
LUAD	Female	All	+0.333	<.001	9	view →
HNSC	Male	All	+0.344	<.001	8	view →
CCRCC	Male	All	+0.185	<.001	6	view →
LSCC	Male	All	+0.251	<.001	5	view →
OV	All	All	+0.420	.023	2	view →
PDAC	All	All	+0.147	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

SRSF4–COAD

Open the COAD breakdown →