SRSF3

Across TCGA pan-cancer cohorts, SRSF3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SRSF3 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SRSF3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SRSF3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

LUAD, COAD, and HNSC are the cancer types where SRSF3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.966	0.667	.001	32	view →
COAD	DFS	Median	All	1.000	0.888	.023	24	view →
HNSC	DFS	Tertile	III,IV	0.670	0.888	.009	20	view →
LSCC	OS	Quartile	All	0.933	0.638	.013	11	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SRSF3–LUAD (DFS)

Open the LUAD breakdown →