SRSF2

Across TCGA patient cohorts, SRSF2 mutation is significantly associated with the RNA expression of many other genes, with 180 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF2-associated genes across cancer lineages are LINC02013, LINC02760, and MIR8082. Each is linked with SRSF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRSF2-to-partner and partner-to-SRSF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02013 grouped by SRSF2-low versus SRSF2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF2→partner) and Y-score (partner→SRSF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02013 →	+0.042	+4.252	<.001	.006	3	3
BLCA	LINC02760 →	+0.086	+5.444	<.001	.002	3	2
UCEC	MIR8082 →	+0.441	+2.976	<.001	.004	3	2
CESC	LINC02293 →	+0.147	+3.464	<.001	.005	3	2
BLCA	GNG5P5 →	+0.163	+5.618	<.001	.002	3	2
LUSC	RPL29P32 →	+0.103	+5.882	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 180 associations by consensus.

LINC02013 by SRSF2 expression — CESC

Explore this box plot interactively →