SRSF2

Across TCGA patient cohorts, SRSF2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF2-associated genes across cancer lineages are ATM, ACC1, and JNK_pT183_Y185. Each is linked with SRSF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF2-to-partner and partner-to-SRSF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SRSF2-low versus SRSF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF2→partner) and Y-score (partner→SRSF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.695	-3.000	.007	.037	3	2
UCEC	ACC1 →	+0.521	+2.820	.013	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.260	-2.986	.007	.037	3	1
UCEC	Notch1 →	+0.186	+3.000	.022	.037	3	1
UCEC	AR →	-0.470	-3.000	.029	.037	3	1
UCEC	EGFR_pY1068 →	-0.393	-3.000	.006	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ATM by SRSF2 expression — UCEC

Explore this box plot interactively →