SRSF11

Across TCGA pan-cancer cohorts, SRSF11 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated SRSF11 data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRSF11 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRSF11 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where SRSF11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.094	0.710	<.001	36	view →
BRCA	DFS	Median	All	0.125	0.528	<.001	26	view →
SKCM	OS	Median	All	0.230	0.781	.004	15	view →
BLCA	DFS	Median	All	0.100	0.626	<.001	12	view →
LGG	OS	Median	All	0.187	0.909	<.001	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
CHOL	DFS	Median	All	0.121	0.495	.024	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	DFS	Median	All	1.000	0.653	.045	1	view →
COAD	OS	Median	All	0.570	0.870	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

SRSF11–HNSC (DFS)

Open the HNSC breakdown →