Across TCGA pan-cancer cohorts, SRSF10 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SRSF10 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRSF10 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRSF10 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, LUAD, and GBM are the cancer types where SRSF10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.264	0.886	.002	64	view →
LUAD	DFS	Quartile	All	0.911	0.268	<.001	15	view →
GBM	OS	Median	All	0.479	0.294	.016	6	view →
PDAC	OS	Tertile	III,IV	0.639	0.871	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SRSF10 tumor-vs-normal RNA expression · all SRSF10 data types