Across TCGA patient cohorts, SRSF10 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF10-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and JNK2. Each is linked with SRSF10 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF10-to-partner and partner-to-SRSF10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF10→partner) and Y-score (partner→SRSF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.347	-3.807	.002	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.164	-1.986	.030	.032	3	1
UCEC	JNK2 →	+0.231	+3.469	.009	.002	3	1
UCEC	Ku80 →	+0.313	+2.713	.003	.003	3	1
UCEC	Notch1 →	+0.165	+2.700	.009	.006	3	1
UCEC	PKC-a →	+0.429	+3.013	.018	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

SRSF10 survival (RNA) · tumor vs normal (RNA) · all SRSF10 data types