SRSF1

Across TCGA pan-cancer cohorts, SRSF1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRSF1 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SRSF1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRSF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, UCEC, and CESC are the cancer types where SRSF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.224	0.700	.002	18	view →
UCEC	DFS	Median	All	1.000	0.630	.026	16	view →
CESC	OS	Median	II,III,IV	0.047	0.830	<.001	12	view →
LIHC	DFS	Median	II,III,IV	0.086	0.429	.009	8	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRSF1–COAD (DFS)

Open the COAD breakdown →