SRSF1

Across TCGA patient cohorts, SRSF1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,365 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SRSF1-associated genes across cancer lineages are CSF3R, CXCL6, and GTF3C4. Each is linked with SRSF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SRSF1-to-partner and partner-to-SRSF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SRSF1 versus CSF3R in LSCC, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF1→partner) and Y-score (partner→SRSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CSF3R →	-1.318	-0.289	<.001	<.001	3	5
LSCC	CXCL6 →	-2.148	-0.283	<.001	<.001	3	5
GBM	GTF3C4 →	+0.541	+0.668	<.001	<.001	3	5
HNSC	FFAR2 →	-1.325	-0.575	<.001	.002	3	5
HNSC	FCGR3B →	-1.719	-0.678	<.001	<.001	3	5
LSCC	WDCP →	+0.496	+0.250	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,365 associations by consensus.

SRSF1 vs CSF3R — LSCC

Explore this scatter interactively →