SRSF1

Across TCGA patient cohorts, SRSF1 mutation is significantly associated with the RNA expression of many other genes, with 2,371 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF1-associated genes across cancer lineages are RNU6-861P, DUXA, and ELMO2P1. Each is linked with SRSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF1-to-partner and partner-to-SRSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-861P grouped by SRSF1-low versus SRSF1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF1→partner) and Y-score (partner→SRSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-861P →	+0.155	+4.842	<.001	.002	3	2
CESC	DUXA →	+0.130	+4.933	<.001	<.001	3	2
CESC	ELMO2P1 →	+0.034	+3.194	.004	.005	3	2
UCEC	RNA5SP412 →	+0.904	+3.104	<.001	<.001	3	2
UCEC	LINC02522 →	+0.499	+1.905	.002	.005	3	2
UCEC	VN1R67P →	+0.101	+2.139	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,371 associations by consensus.

RNU6-861P by SRSF1 expression — CESC

Explore this box plot interactively →