SRSF1

Across TCGA patient cohorts, SRSF1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF1-associated genes across cancer lineages are Notch1, Rad50, and Annexin-1. Each is linked with SRSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF1-to-partner and partner-to-SRSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SRSF1-low versus SRSF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF1→partner) and Y-score (partner→SRSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.205	+3.000	<.001	.001	3	2
UCEC	Rad50 →	-0.250	-2.446	.012	.018	3	2
UCEC	Annexin-1 →	+0.816	+2.479	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.248	-1.807	.016	.027	3	1
UCEC	A-Raf_pS299 →	-0.140	-3.459	.004	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.156	-1.794	.024	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Notch1 by SRSF1 expression — UCEC

Explore this box plot interactively →