SRSF1

Across TCGA cell cohorts, SRSF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,024 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRSF1-associated GO terms across cancer lineages are Regulation of DNA-templated DNA replication, Sister chromatid cohesion, and DNA-templated DNA replication maintenance of fidelity. Each is linked with SRSF1 in more than 19 cancer types. Because this analysis shows association rather than direction, both SRSF1-to-partner and partner-to-SRSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated DNA replication grouped by SRSF1-low versus SRSF1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF1→partner) and Y-score (partner→SRSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of DNA-templated DNA replication →	+0.144	+0.860	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Sister chromatid cohesion →	+0.110	+0.667	.001	.003	3	20
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.111	+0.677	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Double-strand break repair via homologous recombination →	+0.085	+0.657	.001	.001	3	19
LUNG_NSCLC_LUSC	Recombinational repair →	+0.082	+0.777	.001	.001	3	19
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.274	+1.334	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,024 associations by consensus.

Regulation of DNA-templated DNA replication by SRSF1 expression — BONE

Explore this box plot interactively →