SRRM4

Across TCGA patient cohorts, SRRM4 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRRM4-associated genes across cancer lineages are mTOR_pS2448, eIF4E, and Caspase-7-cleavedD198. Each is linked with SRRM4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SRRM4-to-partner and partner-to-SRRM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SRRM4-low versus SRRM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRM4→partner) and Y-score (partner→SRRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.105	-1.794	.023	.024	3	4
UCEC	eIF4E →	+0.144	+1.906	.028	.015	3	3
COAD	Caspase-7-cleavedD198 →	+1.071	+2.476	<.001	.009	3	3
UCEC	14-3-3_beta →	-0.087	-2.973	.005	<.001	3	2
UCEC	A-Raf_pS299 →	-0.109	-1.440	.003	.022	3	2
UCEC	JNK_pT183_Y185 →	-0.134	-1.584	.010	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

mTOR_pS2448 by SRRM4 expression — UCEC

Explore this box plot interactively →