SRRM3

Across TCGA patient cohorts, SRRM3 mutation is significantly associated with the RNA expression of many other genes, with 709 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRRM3-associated genes across cancer lineages are MTND2P25, CD24P1, and RNU6-225P. Each is linked with SRRM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRRM3-to-partner and partner-to-SRRM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND2P25 grouped by SRRM3-low versus SRRM3-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRM3→partner) and Y-score (partner→SRRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MTND2P25 →	+0.075	+6.902	<.001	<.001	3	2
LIHC	CD24P1 →	+0.169	+5.878	<.001	.002	3	2
BLCA	RNU6-225P →	+0.352	+7.640	<.001	.009	3	2
UCEC	MTCO2P24 →	+0.097	+3.110	<.001	.006	3	2
LIHC	BUB1P1 →	+0.070	+5.447	<.001	.005	3	1
UCEC	ZFP91P1 →	+0.140	+2.233	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 709 associations by consensus.

MTND2P25 by SRRM3 expression — LIHC

Explore this box plot interactively →