SRRM3

Across TCGA patient cohorts, SRRM3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRRM3-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and mTOR_pS2448. Each is linked with SRRM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRRM3-to-partner and partner-to-SRRM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SRRM3-low versus SRRM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRM3→partner) and Y-score (partner→SRRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.340	+3.009	.006	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.135	-2.459	.025	.020	3	1
UCEC	mTOR_pS2448 →	-0.161	-2.459	.025	.020	3	1
UCEC	Notch1 →	+0.181	+2.817	.007	.036	3	1
UCEC	P-Cadherin →	-0.153	-2.999	.028	.035	3	1
UCEC	BRD4 →	+0.348	+3.329	.013	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FoxM1 by SRRM3 expression — UCEC

Explore this box plot interactively →