SRRM3

Across TCGA cell cohorts, SRRM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,993 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SRRM3-associated GO terms across cancer lineages are Negative regulation of glucagon secretion, Cellular respiration, and Mitochondrial electron transport, ubiquinol to cytochrome c. Each is linked with SRRM3 in more than 18 cancer types. Because this analysis shows association rather than direction, both SRRM3-to-partner and partner-to-SRRM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of glucagon secretion grouped by SRRM3-low versus SRRM3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRM3→partner) and Y-score (partner→SRRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of glucagon secretion →	+1.794	+2.246	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Cellular respiration →	+0.088	+1.726	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Mitochondrial electron transport, ubiquinol to cytochrome c →	+0.073	+1.281	<.001	<.001	3	11
STOMACH	ATP metabolic process →	+0.093	+2.109	<.001	<.001	3	11
SKIN	Proton transmembrane transport →	+0.076	+1.327	<.001	.001	3	11
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.106	+2.040	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,993 associations by consensus.

Negative regulation of glucagon secretion by SRRM3 expression — OESOPHAGUS

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