SRRM3

Across TCGA cell cohorts, SRRM3 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRRM3-associated genes across cancer lineages are IL3, SCGB1D1, and OR9K2. Each is linked with SRRM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRRM3-to-partner and partner-to-SRRM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by SRRM3-low versus SRRM3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRM3→partner) and Y-score (partner→SRRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL3 →	+0.052	+5.614	<.001	<.001	3	1
LUNG_SCLC	SCGB1D1 →	+2.546	+4.269	<.001	.005	3	1
LUNG_SCLC	OR9K2 →	+0.038	+4.817	<.001	.001	3	1
LUNG_SCLC	OR10T2 →	+0.145	+4.044	.002	.009	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

IL3 by SRRM3 expression — LUNG_SCLC

Explore this box plot interactively →