SRRM2

Across TCGA pan-cancer cohorts, SRRM2 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SRRM2 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SRRM2 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated SRRM2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, DLBC, and UCS are the cancer types where SRRM2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.975	0.853	<.001	36	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	30	view →
UCS	OS	Median	II,III,IV	0.001	0.616	<.001	24	view →
THCA	DFS	Median	All	0.049	0.828	<.001	18	view →
BRCA	OS	Median	III,IV	0.027	0.907	<.001	12	view →
LUAD	OS	Median	III,IV	0.502	0.662	<.001	7	view →
SKCM	DFS	Median	II,III,IV	0.512	0.201	.009	7	view →
SCLC	OS	Median	II,III,IV	0.189	0.579	.027	3	view →
ACC	DFS	Median	All	0.209	0.659	.027	3	view →
BLCA	DFS	Median	IV	0.126	0.479	.019	3	view →
HNSC	DFS	Median	IV	1.000	0.305	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SRRM2–UCEC (OS)

Open the UCEC breakdown →