SRRM2

Across TCGA pan-cancer cohorts, SRRM2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SRRM2 data layer compared with 23 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SRRM2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SRRM2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where SRRM2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	1.000	0.307	.012	20	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.595	.003	15	view →
LUAD	DFS	Median	III,IV	0.996	0.485	.001	14	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	8	view →
HNSC	DFS	Tertile	All	0.623	1.000	.040	7	view →
GBM	DFS	Median	All	0.412	0.223	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SRRM2–UCEC (DFS)

Open the UCEC breakdown →