SRRM2

Across TCGA cell cohorts, SRRM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,293 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SRRM2-associated GO terms across cancer lineages are DNA double-strand break processing involved in repair via single-strand annealing, Pre-mRNA catabolic process, and Double-strand break repair via single-strand annealing. Each is linked with SRRM2 in more than 15 cancer types. Because this analysis shows association rather than direction, both SRRM2-to-partner and partner-to-SRRM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA double-strand break processing involved in repair via single-strand annealing grouped by SRRM2-low versus SRRM2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRM2→partner) and Y-score (partner→SRRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DNA double-strand break processing involved in repair via single-strand annealing →	+0.085	+0.751	<.001	<.001	3	16
BONE	Pre-mRNA catabolic process →	+0.235	+1.171	<.001	<.001	3	16
LARGE_INTESTINE	Double-strand break repair via single-strand annealing →	+0.085	+0.751	<.001	<.001	3	16
BONE	Late viral transcription →	+0.132	+1.161	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.178	+1.175	<.001	<.001	3	15
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.232	+1.291	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,293 associations by consensus.

DNA double-strand break processing involved in repair via single-strand annealing by SRRM2 expression — LARGE_INTESTINE

Explore this box plot interactively →