SRRM2

Across TCGA cell cohorts, SRRM2 mutation is significantly associated with the RNA expression of many other genes, with 1,275 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRRM2-associated genes across cancer lineages are PSRC1, GJC1, and FBXO5. Each is linked with SRRM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SRRM2-to-partner and partner-to-SRRM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSRC1 grouped by SRRM2-low versus SRRM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRM2→partner) and Y-score (partner→SRRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PSRC1 →	+0.647	+3.321	.001	.003	3	4
BLOOD_Leukemia	GJC1 →	+1.620	+3.459	<.001	.002	3	3
BLOOD_Leukemia	FBXO5 →	+0.608	+2.730	.004	.001	3	3
LARGE_INTESTINE	MMS22L →	+0.800	+2.036	<.001	.002	3	3
BLOOD_Leukemia	PRRT1 →	+0.672	+2.730	.002	.001	3	3
LARGE_INTESTINE	RANGRF →	+0.515	+2.596	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,275 associations by consensus.

PSRC1 by SRRM2 expression — LARGE_INTESTINE

Explore this box plot interactively →