SRRM1

Across TCGA pan-cancer cohorts, SRRM1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SRRM1 data layer compared with 25 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SRRM1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SRRM1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where SRRM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.935	0.646	.010	16	view →
CCRCC	DFS	Tertile	All	0.849	0.630	.008	15	view →
GBM	DFS	Tertile	All	0.252	0.520	.002	8	view →
HNSC	DFS	Median	IV	0.550	0.771	.021	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SRRM1–LUAD (DFS)

Open the LUAD breakdown →