SRRM1

Across TCGA patient cohorts, SRRM1 mutation is significantly associated with the RNA expression of many other genes, with 2,957 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRRM1-associated genes across cancer lineages are UQCR10, OR10K2, and DTYMK. Each is linked with SRRM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SRRM1-to-partner and partner-to-SRRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCR10 grouped by SRRM1-low versus SRRM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRM1→partner) and Y-score (partner→SRRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UQCR10 →	+0.258	+1.617	.002	.002	3	4
HNSC	OR10K2 →	+0.075	+5.578	<.001	.004	3	4
UCEC	DTYMK →	+0.506	+2.818	<.001	<.001	3	4
HNSC	RNA5SP384 →	+0.567	+5.124	<.001	.008	3	3
SKCM	MRPL52 →	+0.462	+2.813	<.001	.001	3	3
UCEC	AURKB →	+0.458	+1.823	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,957 associations by consensus.

UQCR10 by SRRM1 expression — UCEC

Explore this box plot interactively →