SRRM1

Across TCGA patient cohorts, SRRM1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRRM1-associated genes across cancer lineages are PCNA, Di-Ras3, and eEF2. Each is linked with SRRM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRRM1-to-partner and partner-to-SRRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SRRM1-low versus SRRM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRM1→partner) and Y-score (partner→SRRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.219	+1.736	<.001	<.001	3	3
UCEC	Di-Ras3 →	-0.194	-4.308	<.001	<.001	3	3
UCEC	eEF2 →	+0.326	+1.874	.001	.002	3	2
UCEC	eIF4E →	+0.132	+1.440	.029	.022	3	2
UCEC	ERK2 →	+0.147	+1.938	.008	.001	3	2
UCEC	FOXO3a →	-0.059	-1.259	.041	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

PCNA by SRRM1 expression — UCEC

Explore this box plot interactively →