SRRM1

Across TCGA cell cohorts, SRRM1 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRRM1-associated genes across cancer lineages are GALNTL5, OR10K2, and OR10T2. Each is linked with SRRM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRRM1-to-partner and partner-to-SRRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALNTL5 grouped by SRRM1-low versus SRRM1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRM1→partner) and Y-score (partner→SRRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GALNTL5 →	+0.049	+5.087	<.001	.004	3	1
BREAST	OR10K2 →	+0.038	+4.196	<.001	.006	3	1
BREAST	OR10T2 →	+0.110	+4.196	<.001	.006	3	1
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Leukemia	DEFB108B →	+0.161	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	GUCA2A →	+0.039	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

GALNTL5 by SRRM1 expression — URINARY_TRACT

Explore this box plot interactively →