SRRD

Across TCGA pan-cancer cohorts, SRRD Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SRRD data layer compared with 26 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher SRRD Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRRD expression acts as an unfavorable survival marker.

SCLC, SKCM, and ESCA are the cancer types where SRRD Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	18	view →
SKCM	DFS	Median	All	0.088	0.737	<.001	18	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SRRD–SCLC (DFS)

Open the SCLC breakdown →