SRR

Across TCGA pan-cancer cohorts, SRR mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SRR data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SRR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SRR expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where SRR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.806	0.297	<.001	60	view →
PDAC	DFS	Tertile	II,III,IV	0.576	0.223	<.001	37	view →
HNSC	DFS	Tertile	III,IV	0.911	0.636	.010	33	view →
GBM	DFS	Tertile	All	0.197	0.554	<.001	17	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SRR–CCRCC (DFS)

Open the CCRCC breakdown →