SRR

Across TCGA patient cohorts, SRR protein abundance is significantly associated with the RNA expression of many other genes, with 14,980 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SRR-associated genes across cancer lineages are FAM110D, CTSG, and CD93. Each is linked with SRR in more than 6 cancer types. Because this analysis shows association rather than direction, both SRR-to-partner and partner-to-SRR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SRR versus FAM110D in CCRCC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRR→partner) and Y-score (partner→SRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FAM110D →	+0.716	+0.363	<.001	<.001	3	7
BRCA	CTSG →	+1.188	+0.429	<.001	<.001	3	5
CCRCC	CD93 →	+0.704	+0.372	<.001	<.001	3	5
GBM	SCN2B →	+0.988	+0.401	.001	.005	3	5
BRCA	CD300LG →	+0.773	+0.462	<.001	.005	3	5
UCEC	TNXB →	+1.202	+0.344	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,980 associations by consensus.

SRR vs FAM110D — CCRCC

Explore this scatter interactively →