SRR

Across TCGA patient cohorts, SRR mutation is significantly associated with the RNA expression of many other genes, with 2,520 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRR-associated genes across cancer lineages are SNORD116-10, RN7SL685P, and RNU6ATAC29P. Each is linked with SRR in more than 1 cancer types. Because this analysis shows association rather than direction, both SRR-to-partner and partner-to-SRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-10 grouped by SRR-low versus SRR-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRR→partner) and Y-score (partner→SRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SNORD116-10 →	+0.343	+4.289	<.001	.007	3	2
BLCA	RN7SL685P →	+0.223	+4.850	<.001	<.001	3	2
UCEC	RNU6ATAC29P →	+0.261	+2.163	.007	.005	3	2
HNSC	KRTAP22-2 →	+0.279	+7.954	<.001	.008	3	1
BLCA	OR13J1 →	+0.176	+3.773	<.001	.006	3	1
BLCA	INSL5 →	+0.146	+3.725	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,520 associations by consensus.

SNORD116-10 by SRR expression — BLCA

Explore this box plot interactively →