SRR

Across TCGA patient cohorts, SRR mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRR-associated genes across cancer lineages are c-Met_pY1235, JNK_pT183_Y185, and PCNA. Each is linked with SRR in more than 1 cancer types. Because this analysis shows association rather than direction, both SRR-to-partner and partner-to-SRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by SRR-low versus SRR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRR→partner) and Y-score (partner→SRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.094	+2.179	.008	.034	3	2
UCEC	JNK_pT183_Y185 →	-0.210	-3.321	.009	.010	3	1
UCEC	PCNA →	+0.292	+3.169	.005	.019	3	1
UCEC	PDCD4 →	-0.651	-2.312	.004	.034	3	1
UCEC	Src →	+0.200	+2.459	.044	.020	3	1
UCEC	STAT3_pY705 →	-0.544	-3.449	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

c-Met_pY1235 by SRR expression — UCEC

Explore this box plot interactively →