SRPX2

Across TCGA patient cohorts, SRPX2 mutation is significantly associated with the RNA expression of many other genes, with 3,572 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRPX2-associated genes across cancer lineages are MAPK1, CCDC134, and TCF20. Each is linked with SRPX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPX2-to-partner and partner-to-SRPX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK1 grouped by SRPX2-low versus SRPX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPX2→partner) and Y-score (partner→SRPX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK1 →	+0.519	+1.726	<.001	.002	3	2
UCEC	CCDC134 →	+0.452	+1.737	.001	.002	3	2
UCEC	TCF20 →	+0.424	+1.745	<.001	.004	3	2
UCEC	POLE2 →	+0.553	+3.108	<.001	<.001	3	2
UCEC	GNPNAT1 →	+0.621	+1.726	<.001	.002	3	2
UCEC	CDKN3 →	+0.802	+2.332	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,572 associations by consensus.

MAPK1 by SRPX2 expression — UCEC

Explore this box plot interactively →