SRPX2

Across TCGA cell cohorts, SRPX2 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRPX2-associated genes across cancer lineages are 630600, KRAS (G12C) Inhibitor-12, and Pyridostatin. Each is linked with SRPX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPX2-to-partner and partner-to-SRPX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 630600 grouped by SRPX2-low versus SRPX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPX2→partner) and Y-score (partner→SRPX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	630600 →	+0.629	+3.064	.025	.009	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.544	+3.061	.015	.010	3	1
LARGE_INTESTINE	Pyridostatin →	+0.451	+2.807	.016	.044	3	1
LARGE_INTESTINE	IC-87114 →	+0.221	+3.067	.017	.009	3	1
LARGE_INTESTINE	CD532 →	+0.408	+2.807	.025	.032	3	1
LARGE_INTESTINE	Doxorubicin →	+1.008	+2.700	.012	.030	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

630600 by SRPX2 expression — LARGE_INTESTINE

Explore this box plot interactively →