SRPK2

Across TCGA patient cohorts, SRPK2 mutation is significantly associated with the RNA expression of many other genes, with 3,605 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRPK2-associated genes across cancer lineages are RNU6-125P, RNA5SP248, and SNORA40C. Each is linked with SRPK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRPK2-to-partner and partner-to-SRPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-125P grouped by SRPK2-low versus SRPK2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPK2→partner) and Y-score (partner→SRPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-125P →	+0.624	+3.049	.004	.005	3	3
HNSC	RNA5SP248 →	+0.242	+3.517	.006	.008	3	2
HNSC	SNORA40C →	+0.268	+4.912	<.001	<.001	3	2
SKCM	RPS2P36 →	+0.160	+3.799	<.001	.005	3	2
CESC	SGO1P1 →	+0.013	+4.516	<.001	.004	3	2
UCEC	LINC01943 →	+0.557	+3.354	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,605 associations by consensus.

RNU6-125P by SRPK2 expression — COAD

Explore this box plot interactively →