SRPK2

Across TCGA patient cohorts, SRPK2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRPK2-associated genes across cancer lineages are Caspase-7-cleavedD198, A-Raf_pS299, and Bax. Each is linked with SRPK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRPK2-to-partner and partner-to-SRPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SRPK2-low versus SRPK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPK2→partner) and Y-score (partner→SRPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.616	+2.720	.011	.003	3	3
UCEC	A-Raf_pS299 →	-0.185	-3.459	<.001	.005	3	2
UCEC	Bax →	+0.204	+2.594	.039	.006	3	2
UCEC	CDK1 →	+0.161	+3.183	.009	.009	3	2
UCEC	C-Raf →	+0.170	+1.807	.004	.027	3	2
UCEC	Cyclin-D1 →	+0.154	+2.321	.020	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by SRPK2 expression — UCEC

Explore this box plot interactively →