SRPK2

Across TCGA cell cohorts, SRPK2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRPK2-associated genes across cancer lineages are TGM7, CALHM4, and TEX43. Each is linked with SRPK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPK2-to-partner and partner-to-SRPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM7 grouped by SRPK2-low versus SRPK2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPK2→partner) and Y-score (partner→SRPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TGM7 →	+0.013	+5.087	<.001	.004	3	1
BLOOD_Leukemia	CALHM4 →	+0.038	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	TEX43 →	+0.105	+4.969	<.001	.003	3	1
BLOOD_Leukemia	CCT8L2 →	+0.019	+4.874	<.001	.002	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.092	+4.539	<.001	.007	3	1
BLOOD_Leukemia	FAM236A →	+0.126	+5.269	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

TGM7 by SRPK2 expression — URINARY_TRACT

Explore this box plot interactively →