SRP9

Across TCGA patient cohorts, SRP9 mutation is significantly associated with the RNA expression of many other genes, with 415 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRP9-associated genes across cancer lineages are YTHDF3-AS1, IGHV3OR16-8, and LINC01050. Each is linked with SRP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP9-to-partner and partner-to-SRP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YTHDF3-AS1 grouped by SRP9-low versus SRP9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP9→partner) and Y-score (partner→SRP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YTHDF3-AS1 →	+0.714	+3.513	.002	.002	3	1
UCEC	IGHV3OR16-8 →	+0.703	+3.691	.008	.001	3	1
UCEC	LINC01050 →	+0.334	+2.479	<.001	.003	3	1
UCEC	CCL5 →	+1.443	+3.480	.001	.002	3	1
UCEC	LINC02084 →	+0.632	+3.354	<.001	.005	3	1
UCEC	IGHV2-70 →	+2.403	+3.467	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 415 associations by consensus.

YTHDF3-AS1 by SRP9 expression — UCEC

Explore this box plot interactively →