SRP9

Across TCGA patient cohorts, SRP9 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRP9-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tem, and CLP. Each is linked with SRP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP9-to-partner and partner-to-SRP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by SRP9-low versus SRP9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP9→partner) and Y-score (partner→SRP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ T-cells →	+0.018	+2.260	.002	.037	3	1
UCEC	CD8+ Tem →	+0.003	+4.606	<.001	.044	3	1
UCEC	CLP →	-0.064	-2.279	.043	.036	3	1
UCEC	DC →	+0.025	+2.667	.014	.011	3	1
UCEC	Memory B-cells →	+0.038	+2.236	.005	.013	3	1
UCEC	aDC →	+0.143	+2.332	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CD8+ T-cells by SRP9 expression — UCEC

Explore this box plot interactively →