SRP9

Across TCGA cell cohorts, SRP9 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,344 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRP9-associated GO terms across cancer lineages are Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery, Regulation of metaphase/anaphase transition of cell cycle, and Positive regulation of mitochondrial ATP synthesis coupled electron transport. Each is linked with SRP9 in more than 13 cancer types. Because this analysis shows association rather than direction, both SRP9-to-partner and partner-to-SRP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery grouped by SRP9-low versus SRP9-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP9→partner) and Y-score (partner→SRP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.115	+0.737	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.105	+1.016	.001	<.001	3	14
OESOPHAGUS	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.131	+0.706	.005	.006	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA damage checkpoint →	+0.115	+1.300	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.107	+0.982	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of sister chromatid segregation →	+0.105	+1.027	.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,344 associations by consensus.

Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery by SRP9 expression — LUNG_SCLC

Explore this box plot interactively →