SRP72

Across TCGA pan-cancer cohorts, SRP72 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SRP72 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRP72 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SRP72 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where SRP72 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.910	0.663	.001	46	view →
PDAC	DFS	Median	III,IV	0.230	0.469	.005	10	view →
LSCC	DFS	Median	III,IV	0.635	0.932	.013	4	view →
GBM	DFS	Quartile	All	0.241	0.413	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SRP72–HNSC (DFS)

Open the HNSC breakdown →