SRP68

Across TCGA pan-cancer cohorts, SRP68 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRP68 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SRP68 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SRP68 expression acts as an unfavorable survival marker.

SKCM, OV, and STAD are the cancer types where SRP68 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.253	0.784	<.001	19	view →
OV	OS	Median	All	0.361	0.841	.038	18	view →
STAD	OS	Median	III,IV	0.003	0.630	<.001	14	view →
BLCA	OS	Median	IV	0.130	0.599	.002	12	view →
COAD	OS	Median	II,III,IV	0.284	0.606	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRP68–SKCM (OS)

Open the SKCM breakdown →