SRP68

Across TCGA pan-cancer cohorts, SRP68 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRP68 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRP68 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SRP68 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LSCC are the cancer types where SRP68 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	1.000	0.291	.001	51	view →
UCEC	DFS	Median	III,IV	1.000	0.274	.001	28	view →
LSCC	DFS	Median	III,IV	0.625	0.932	.010	4	view →
PDAC	OS	Quartile	III,IV	0.247	0.538	.012	3	view →
CCRCC	OS	Quartile	All	0.759	0.929	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRP68–HNSC (DFS)

Open the HNSC breakdown →